🔈 ANATOMY OF THE SCIATIC NERVE Several important nerves arise from the sacral plexus and either supply the gluteal region (e.g., superior and inferior gluteal nerves) or pass through it to supply perineum and thigh (e.g., the pudental and sciatic nerves, respectively). Sciatic Nerve is the largest nerve in the body and is the continuation of the main part of the sacral plexus. The branches converge at the inferior border of the piriformis to form the sciatic nerve, a thick, flattened band approximately 2cm wide. The sciatic nerve is the most lateral structure emerging through the greater sciatic foramen inferior to the piriformis. Medial to the sciatic nerve are the inferior gluteal nerve and vessels, the internal pudendal vessels, and the pudendal nerve. The sciatic nerve runs inferolaterally under cover of the gluteus maximus, midwy between the greater trochanter and ischial tuberosity. The nerve rests on the ischium and then passes posterior to the obturator internus, quadratus femoris and adductor magnus muscles. The sciatic nerve is so large that it receives a named branch of the inferior gluteal artery, the artery to the sciatic nerve.